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Ionimed Analytik GmbH perform research and provide analytical instruments for the medical and biotechnology fields based on the technique of proton-transfer-reaction mass spectrometry (PTR-MS) and supply gas calibration equipment for use with our PTR-MS and other trace gas detectors.
 
Ionimed in the Biotechnology


Ionimed in the Biotech Industry

Monitoring of production processes in the biotech industry at present relies predominantly on off-line sampling and direct analysis techniques. Our goal is to provide a tool to improve this procedure by enabling online production monitoring. This type of direct monitoring technique is the part of process analytical technology (PAT) initiative currently being recommended by the US Food and Drugs Administration (FDA) to improve quality, safety and efficiency in drug manufacturing processes. Using PTR-MS we can measure volatile organic compounds (VOCs) in the headspace air of a fermentor. These VOCs arise as a result of microbiological activity during a fermentation process and provide an indication of the current status and development of a production batch.

 

Our expertise in the field of biotech research has been furthered by our inclusion in the Austrian Centre of Biopharmaceutical Technology (ACBT) , which we joined in July 2006. The main objective of ACBT is "to achieve a significant improvement in efficiency of biopharmaceutical process development ... to provide widely optimised manufacturing processes for clinical trials and mass production of biopharmaceuticals". 

 

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Our work in ACBT includes collaborations with academic as well as industry partners. Within the framework of this competence centre we are using PTR-MS as a PAT tool to monitor and identify VOCs produced during fermentations, with the ultimate aim to enable online process monitoring and control. 

Below are two examples of fermentation processes that have been monitored with PTR-MS. The different compounds show varying time evolutions throughout the processes, which can be used to monitor the status of the fermentation. 

 

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It is envisioned that online monitoring with PTR-MS in future will be an essential tool for optimisation of pharmaceuticals production, helping to provide cost-effective development and manufacture of new and already established medications and other pharmaceutical products.

 
Ionimed Analytik GmbH perform research and provide analytical instruments for the medical and biotechnology fields based on the technique of proton-transfer-reaction mass spectrometry (PTR-MS) and supply gas calibration equipment for use with our PTR-MS and other trace gas detectors.
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Providing Expert Solutions for Trace Gas Analysis
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